Antidepressant Tolerability and Potential Clinical Implications of Serotonin-2A Genotypes
نویسنده
چکیده
Since the introduction of monoamine oxidase inhibitors (MAOIs) in the 1950s, researchers have been searching for antidepressant agents with more favorable tolerability profiles. The introduction of selective serotonin reuptake inhibitors (SSRIs) in the late 1980s provided clinicians with a drug class featuring an improved tolerability profile as compared to MAOIs and tricyclic antidepressants (TCAs), as well as a much wider therapeutic index [1,2].
منابع مشابه
Pharmacogenetics of antidepressant medication intolerance.
OBJECTIVE The authors sought to identify genetic markers for antidepressant medication intolerance. Genetic variation in drug metabolizing enzymes such as cytochrome P450 2D6 (CYP2D6) has been postulated to underlie antidepressant intolerance (pharmacokinetic effect). However, variation in genes encoding serotonin receptors could also explain antidepressant side effects (pharmacodynamic effect)...
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